San Francisco generally recovers from early season slumps. Geno Smith generally loses to the Niners — he’s 0-3 against them all-time with a passer rating more than 10 points lower against his divisional rival than his Seattle average. The Bears’ defense is absolutely legit and this rookie QB they’ve got might not be too bad, either!

The Indianapolis Colts and Tennessee Titans are trying to stay within shouting distance of the AFC South-leading Houston Texans.

Mike Florio and Chris Simms evaluate if the 49ers can win a crucial game against the Seahawks without Christian McCaffrey in Week 6.

NFL Week 6 schedule begins with San Francisco 49ers at Seattle Seahawks on Thursday Night Football. Find the Week 6 NFL TV lineup and how to watch.

T eams looking to turn their recent fortunes around clash when the San Francisco 49ers face the Seattle Seahawks in a key NFC West matchup on Thursday Night Football. San Francisc

Understanding problematic injuries and identifying viable contingency plans before the Sunday morning add-drop frenzy gives savvy re-draft managers an advantage over the competition. The article below details the top five NFL injuries and contingency plans to know for Week 6.

Each NFL squad is faced with injuries, and the complete list is provided here as we look ahead to the Week 6 NFL slate of games, with lots of pivotal players in danger of being unavailable. The article below will show the latest practice and game status for each game as teams provide new information,